2021 Panini Prizm Baseball brings the popular Optichrome cards to the diamond. The set is a licensed product by the Major League Baseball Players Association (MLBPA) which means the cards will include the top rookies, veterans, and stars who are members of the MLBPA, but it will not have any official trademarks of the MLB such as team logos. The base set holds 250 total cards and divides them up into three tiers - the Common Base Set, the rarer Tier II, and the rarest Tier III. There will also be a handful of autograph subsets including Rookie Autographs for players such as Jo Adell, Cristian Pache, and Casey Mize. Some of the biggest stars in the modern game will also have autograph cards in the Signatures subset such as Vladimir Guerrero Jr. and Fernando Tatis Jr.

The 2021 Panini Prizm Baseball Hobby Box comes in the same format as most other Prizm Hobby Boxes holding 12 cards per pack, and 12 packs per box. Inside, you can look to find three autographs, five Red Prizm parallels, four Blue Prizm parallels, and three Silver Prizm parallels. Additionally, you will receive three serial-numbered Prizm parallels with limited print runs. The 2021 Panini Prizm Baseball Hobby Boxes also offer the opportunity to find rare Giraffe Prizm parallels.

The 2021 Panini Prizm Baseball Hobby Box released on August 13, 2021.